2026 Mercedes‑Benz E 350 sedan:

⛽ EPA City / Highway Fuel Economy (2026 E 350)

• City: ~24‑25 mpg (depends on drivetrain) 

• Highway: ~33 mpg

• Combined: ~28 mpg

🚗 Details & Variations

• Rear‑wheel‑drive (RWD) E 350: EPA lists about 25 mpg city / 33 mpg highway. 

• All‑wheel‑drive (4MATIC) E 350: EPA shows about 24 mpg city / 33 mpg highway. 

These figures are for the 2.0 L turbocharged mild‑hybrid inline‑4 used in the E 350, paired with a 9‑speed automatic transmission — blending performance with reasonable fuel economy for a midsize luxury sedan. 

---

📊 What This Means in Real Driving

• City driving: Around 24‑25 mpg during stop‑and‑go traffic, where the engine cycles frequently and mild‑hybrid assist helps efficiency. 

• Highway cruising: Around 33 mpg at steady speeds — typical for a luxury sedan cruising on freeways. 

---

If you’d like, I can also estimate real‑world range (approximate miles per a full tank) based on these mpg figures and the E 350’s fuel tank size.